Calm

Earths Secret Calm Complex was created to help relieve Modern Life Stress and to aid concentration and focus throughout the day. Our Calm Complex contains the worlds leading adaptogen KSM-66® Ashwagandha, which is the most bioavailable form of Ashwagandha on the market today. Combined with four other powerful botanicals containing Ayurvedic Adaptogens and Natural Nootropics. 

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Organic KSM-66® Ashwagandha

Why Organic KSM-66® Ashwagandha?

Calm's Pillar ingredient is KSM-66® Ashwagandha, which is a branded peer-patented form of Ashwagandha. Being the highest concentrated, full spectrum root extract on the market today. KSM-66® Ashwagandha has the highest percentage of withanolides (active compounds) compared to any other root-only extract, measuring over 5% by HPLC and uses a special ‘green-chemistry’ extraction process without the use of alcohol or synthetic solvents. KSM-66® is the number one clinically studied version of Ashwagandha, which has 22 gold standard human clinical trials, demonstrating its profound effect on reducing stress and anxiety. 

Ashwagandha comes from a root found in India which has been used as a stress reliever tonic in many Ayurvedic traditions. In Sanskrit, Ashwagandha means “smell of horse” as it imparts the strength and vigor of a stallion. The Ashwagandha plant is renowned for being one of the most powerful Ayurvedic herbs with many effects for the body and mind, that spans back thousands of years. Ashwagandha optimises the body's stress response by lowering cortisol levels and promoting a calmer, clearer state of mind. Clinically proven to reduce the feelings of anxiety by supporting the productions of mood-stabilising brain chemicals. Ashwagandha has also been shown to boost acetylcholine in the brain, which can improve memory, learning and cognition. Ashwagandha is classified as an Adaptogen, meaning that it can help the body better deal with stress and can return you to a state of balance and homeostasis when things get out of sync. Ashwagandha has been shown to enhance GABA receptors and Serotonin in the brain. It appears to work on neuron receptors, enabling GABA to connect easier, which inhibits the signals present under a stress response in the brain.

Clinical Studies

  • A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root (KSM-66®) in reducing stress and anxiety in adults. The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract (KSM-66®) safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life.
  • A study shows 20 healthy males given 250 mg capsules of standardized Ashwagandha extract for 14 days. There were significant improvements in reaction times. The study suggests that Ashwagandha extract can improve cognitive and psychomotor (physical reaction) performance.
  •  A Double-Blind, Randomized, Placebo-Controlled Trial tested the body weight management in adults under chronic stress through treatment With Ashwagandha Root Extract. The outcome of this study suggests that Ashwagandha root extract can be used for body weight management in adults under chronic stress.
  • After eight weeks of study, the Ashwagandha treatment group demonstrated significant improvements compared with the placebo group in both immediate and general memory. The treatment group also demonstrated significantly greater improvement in executive function, sustained attention, and information-processing. This study suggests, Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.
  • A study suggests that, KSM-66 Ashwagandha increased telomerase activity through TRAP assay, with highest enhancement of ~45% at 10-50μg concentration. This shows that Ashwagandha root extract has anti-aging inducing potential
  • A study where the efficacy of KSM-66® Ashwagandha was tested for an improvement of cardiorespiratory endurance in healthy athletic adults. The results showed a greater increase from baseline in the mean VO2 max with KSM-66 Ashwagandha compared to placebo at 8 weeks and at 12 weeks. The findings suggest that Ashwagandha root extract enhances the cardiorespiratory endurance and improves QOL in healthy athletic adults.

Holy Basil Extract

Why Holy Basil Extract?

Holy Basil, otherwise known as ‘Tulsi’ is an Ayurvedic herb that works as an Adaptogen through nurturing and nourishing the body, mind and spirit, while fostering a sense of relaxation and wellbeing. In the Ayurveda system Holy Basil is often referred to as an “Elixir of Life”, for its healing powers and has been known to treat many different common health conditions. Holy Basil has been said to be like yoga, with its calming effect that can lead to clarity of thought, along with a more relaxed and calm disposition. In Hinduism, Holy Basil is linked to the figure of a goddess, as it is seen as one of the holiest and cherished plants of the orient. Holy Basil is considered a symbol of fidelity and helpful in attaining spiritual enlightenment. The emerging science on Holy Basil, reinforces ancient Ayurvedic wisdom, as it suggests that it can be used as a tonic for the body, mind and spirit. Holy Basil has also shown to have potential cognition-enhancing properties in humans. 

Clinical Studies

  • There have been four studies on the cognitive effects of supplementation with Holy Basil, the results showed significant improvements in mood and cognitive function.
  • A study conducted in India recruited 35 patients (21 male and 14 female, average age 38.4 years) to investigate using Holy Basil in the treatment of anxiety disorders. Patients were given Holy Basil extract twice daily for 60 days. The patients were assessed at the beginning of the trial, 30 and 60 days. Researchers found Holy Basil significantly reduced general anxiety and relieved the associated stress and depression.

Rhodiola Rosea Extract

Why Rhodiola Rosea Extract?

Rhodiola rosea, known as the ‘Golden Root’ found in the mountainous parts of Europe and Asia, has been traditionally used as an Adaptogen and Nootropic by enhancing mental performance and fighting stress for centuries. The Vikings commonly used Rhodiola Rosea to enhance mental and physical endurance. Studies have shown that Rhodiola may improve cognitive function, reduce mental fatigue, promote free radical mitigation, and increase endurance performance. In Russia, Rhodiola Rosea is widely used as a remedy for energy, poor concentration, decreased memory, and is believed to make workers more productive. The plant's popularity made worldwide headlines when research leaked that the Russians were using the herb for its energy and health inducing properties on Olympians and Soldiers in the 70s. Rhodiola Rosea is said to be the ideal study Nootropic as research shows the increase to detail-oriented tasks by improving concentration over a prolonged period and boosting energy, by increasing the ATP synthesis in your mitochondria. Rhodiola Rosea has been used traditionally to boost mood by influencing norepinephrine levels in your brain, and the feel-good hormones like beta-endorphins.

Clinical Studies

  • A double- blind, placebo controlled trial with subjects aged 18-70 with mild to moderate depression were given Rhodiola Rosea extract daily. The research team reported significant improvements in depression, emotions and overall quality of life. 
  • One double-blind, placebo-controlled trial was carried out with 161 cadets aged from 19 – 21 years. The intent was to measure the effect of a single dose of Rhodiola Rosea extract on capacity for mental work against a background of fatigue and stress. The study showed a “pronounced anti-fatigue effect” in the cadets. 
  • Another study was done with the aim to investigate the effect of repeated low-dose treatment of Rhodiola Rosea extract on mental performance with fatigued physicians. The research team found a statistically significant improvement in cognitive tests during the first 2 weeks. No side effects were reported. And the young doctors had a reduction in general fatigue under stressful conditions

L-theanine

Why L-theanine?

L-theanine is a natural occurring amino acid found in Green Tea leaves and some mushrooms. L-theanine gives Green Tea many of its cognitive-enhancement and relaxing qualities without drowsiness. L-Theanine is known as a Nootropic as it has been shown to boost Alpha and Theta brain waves, which may promote alert relaxation and enhance creativity. The effects of L-theanine have said to provide a sense of calm and clear-headed focus. L- theanine may increase GABA, serotonin and dopamine levels in your brain which can have an energising and calming effect on your mood. 

Clinical Studies

  • A 4 week study of L-theanine supplementation was shown to have positive effects in improving stress-related symptoms and cognitive-enhancement in healthy adults. 
  • A study in South Korea worked with 20 healthy male volunteers aged 18 – 30 years. One group was given L-Theanine tablets, and the other group a placebo daily for 7 days. Brain waves were measured 40 minutes after administration of L-Theanine researchers analysed alpha wave power values. The results concluded that L- Theanine promoted the release of alpha brain waves related to mental relaxation and concentration.
  • Another study done in Japan worked with 12 people who underwent 4 separate trials. One in which they took L-Theanine at the start of the experiment. One in which they took it half-way through. And two control trials in which they took either a placebo or nothing. The results concluded that L-Theanine could cause anti-stress effects via the inhibition of cortical neuron excitation.

Black Pepper

Why Black Pepper?

Black pepper is added to enhance the absorption and bioavailability of Ashwagandha. Known as a ‘bio-enhancer’ as the bioactive compound found in Black Pepper, 'Piperine’ has shown to increase bioavailability of different herbs ranging from 30% to 200%. The concept of ‘bioavailability enhancers’ is derived from the traditional age old system of Ayurveda (science of life).

References

Organic KSM-66® Ashwagandha

  1. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(6) Bhattacharya, S. K., Bhattacharya, A., Sairam, K., & Ghosal, S. (2000).
  2. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Salve, J., Pate, S., Debnath, K., & Langade, D. (2019).
  3. Cholinesterase inhibiting withanolides from Withania somnifera. Chemical & pharmaceutical bulletin, Choudhary, M. I., Yousuf, S., Nawaz, S. A., Ahmed, S., & Atta-ur-Rahman (2004).
  4. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy research, 6(1), 12–18. Pingali, U., Pilli, R., & Fatima, N. (2014).
  5. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255–262. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012)
  6. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults . Ayu, 36(1), 63. Choudhary, B., Shetty, A., & Langade, D. G. (2015)
  7. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomised controlled trial Wankhede. Journal of the International Society of Sports Nutrition, 12(1), 43. S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015)
  8. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study Dongre,BioMed research international, 2015. S., Langade, D., & Bhattacharyya, S. (2015).
  9. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomised, Placebo-Controlled Trial). Journal of evidence-based complementary & alternative medicine, 22(1), 96-106. Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017)
  10. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions). Journal of Dietary Supplements, 1-14. Chicago Choudhary, D., Bhattacharyya, S., & Bose, S. (2017)
  11. Withania somnifera root extract extends lifespan of Caenorhabditis elegans . Annals of neurosciences, 20(1), 13. Kumar, R., Gupta, K., Saharia, K., Pradhan, D., & Subramaniam, J. R. (2013)
  12. Withania somnifera Root Extract Enhances Telomerase Activity in the Human HeLa Cell Advances in Bioscience and Biotechnology, 7(04), 199. Line Raguraman, V., & Subramaniam, J. R. (2016).
  13. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomised Placebo-Controlled Trial.. The Journal of Alternative and Complementary Medicine. Sharma, A. K., Basu, I., & Singh, S. (2017)
  14. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Panossian A, Wikman G. Curr Clin Pharmacol. 2009;4:198–219.
  15. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males. American journal of men's health, 13(2) Lopresti, A. L., Drummond, P. D., & Smith, S. J. (2019).
  16. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Journal of alternative and complementary medicine (New York, N.Y.), 20(12), 901–908. Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014).

Rhodiola Rosea

  1. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current pharmacology reports, 3(6), 384–395. Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). 
  2. Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Front Pharmacol. 2018;9:1415. Ma GP, Zheng Q, Xu MB, et al.
  3. ‘Rhodiola rosea L. as a putative botanical antidepressant’ Phytomedicine. 2016 Jun 15;23(7):770–83. Amsterdam JD, Panossian AG.
  4. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms’ Phytother Res. 2015 Dec;29(12):1934–9.Cropley M, Banks AP, Boyle J
  5. ‘Reflection Paper on the Adaptogenic Concept’ Committee on Herbal Medical Products (PDF) 8 May 2008. European Medicines Agency (2008) 
  6. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.’ Phytomedicine. 2011 Feb 15;18(4):235–44. doi: 10.1016/j. phymed.2010.08.014. Epub 2010 Oct 30 Hungk SK, Perry R, Ernst E (2011) 
  7. Rhodiola rosea for physical and mental fatigue: a systematic review.’ BMC Complement Altern Med. 2012 May 29;12:70. Ishaque S, Shamseer L, Bukutu C, Vohra S (2012) 
  8. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial’ Phytomedicine. 2015 Mar Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD 
  9. A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots of Rhodiola rosea in the Treatment of Subjects with Stress-Related Fatigue’. Planta Med. 2009 Feb;75(2):105–12. Olsson EM, Von Sheele B, Panossian AG (2009) 
  10. Randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine : international journal of phytotherapy and phytopharmacology. 10. 95-105. Shevtsov, V.A. & Zholus, B.I. & Shervarly, V.I. & Vol'skij, V.B. & Korovin, Y.P. & Khristich, M.P. & Roslyakova, N.A. & Georg, Wikman. (2003).
  11. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine : international journal of phytotherapy and phytopharmacology, 7(5), 365–371. Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000).

Holy Basil

  1. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature.” Evidence-based complementary and alternative medicine : eCAM vol. 2017 (2017) Jamshidi, Negar, and Marc M Cohen.  
  2. Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine, 5(4), 251–259. Cohen M. M. (2014).
  3. Tulsi: The Mother Medicine of Nature. 2nd ed. Lucknow: International Institute of Herbal Medicine; 2010. pp. 28–47 Singh N, Hoette Y, Miller R.
  4.  Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study. Evidence-based complementary and alternative medicine : eCAM, 2012, 894509. Saxena, R. C., Singh, R., Kumar, P., Negi, M. P., Saxena, V. S., Geetharani, P., Allan, J. J., & Venkateshwarlu, K. (2012)
  5. Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Medical College journal Bhattacharyya, D., Sur, T. K., Jana, U., & Debnath, P. K. (2008).
  6. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian journal of physiology and pharmacology, 49(2), 125–131. Prakash, P., & Gupta, N. (2005).
  7. Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer. Nutrition and cancer, 65 Suppl 1, 26–35. Baliga, M. S., Jimmy, R., Thilakchand, K. R., Sunitha, V., Bhat, N. R., Saldanha, E., Rao, S., Rao, P., Arora, R., & Palatty, P. L. (2013). 
  8. Chemical composition and antioxidant property of holy basil (Ocimum sanctum L.) leaves, stems, and inflorescence and their in vitro callus cultures. Journal of agricultural and food chemistry, 55(22), 9109–9117. Hakkim, F. L., Shankar, C. G., & Girija, S. (2007).

L-theanine

  1. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). 
  2. Theanine, r-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation. Life sciences, 81(16), 1247–1255. Yamada, T., Terashima, T., Wada, K., Ueda, S., Ito, M., Okubo, T., Juneja, L. R., & Yokogoshi, H. (2007). 
  3. Effects of Theanine on the Release of Brain Alpha Wave in Adult Males. Korean Journal of Nutrition, 36(9), 918–923. Song, C. H., Jung, J. H., Oh, J. S., & Kim, K. S. (2003).
  4. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology, 232(14), 2563–2576. Dodd, F. L., Kennedy, D. O., Riby, L. M., & Haskell-Ramsay, C. F. (2015)
  5. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: A systematic review and meta-analysis. Nutrition reviews. Camfield, David & Stough, Con & Farrimond, Jonathon & Scholey, Andrew. (2014). 
  6. L-Theanine reduces psychological and physiological stress responses. Biological psychology, 74(1), 39–45. Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007).
  7. Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutritional neuroscience, 17(4), 145–155. Lardner A. L. (2014).

Black Pepper

  1. Bioavailability enhancers of herbal origin: an overview. Asian Pacific journal of tropical biomedicine, 3(4), 253–266.Kesarwani, K., Gupta, R., & Mukerjee, A. (2013).
  2. Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications. Nutrients, 12(6), 1886. Fernández-Lázaro, D., Mielgo-Ayuso, J., Córdova Martínez, A., & Seco-Calvo, J. (2020)
  3. Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies Zorica Stojanovi´c-Radi´c 1,*, Milica Pejˇci´c 1 , Marina Dimitrijevi´c 1 , Ana Aleksi´c 1 , Nanjangud V. Anil Kumar 2 , Bahare Salehi 3,* , William C. Cho 4,* and Javad Sharifi-Rad 5, Published: 2019
  4. Piperine: A comprehensive review of methods of isolation, purification, and biological properties, Medicine in Drug Discovery, Volume 7,2020. Anshuly Tiwari, Kakasaheb R. Mahadik, Satish Y. Gabhe.

Here’s Why People Trust Us To Care For Their Body & Mind

  • We Create Unique Complexes

    We’ve explored all corners of the Earth to find nature’s most potent herbs, plants and fruits for human wellbeing. Individually, these ingredients have been used for centuries. Together, they can truly transform modern wellness. Our complexes use cutting edge science to synergise these ingredients in ways that maximise absorption, giving you the most powerful results. 

  • We’re Backed By Science

    Created by nature, proven by science. Each one of our Pillar ingredients is clinically peer-patented, using cutting edge methods and backed by extensive scientific literature. And because each one harnesses the highest bioavailability of each plant or herb, it’s hardly surprising that all three of our Pillar ingredients have won awards within the health and wellness space. 

  • We Honour Nature

    Our ethos is rooted in a deep respect for mother nature. After all, Earth has given us the gifts we need to nurture our bodies and mind for thousands of years; we simply need to reconnect to this truth. That’s why we use the purest plants, herbs and fruits in our complexes and include zero fillers, anti-caking agents, binders or preservatives. So you just get the good stuff, exactly as nature intended. 

  • We’re Sustainable & Ethically Sourced

    Our company honours what our planet has given us. That’s why we insist on full traceability and transparent suppliers when it comes to a green agenda and we’ve sourced the most eco-friendly options available for our packaging. What’s more, our partnership withOne Tree Planted means that you’re helping to reforest the planet, one order at a time

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