Award winning standardised Saffron extract.

affron® is an Award Winning herb

USA Award-winner Ingredient for Cognitive Health 2020

“An extraordinary Saffron extract of the highest quality, endorsed by 6 human clinical studies, patented, and with well-defined mechanisms of action.”


What is Saffron?

Saffron is a spice derived from the flower of Crocus sativus, it has been used for more than 3,500 years and extends across many cultures, continents, and civilisations.The cultivation of Saffron requires intensive labour and time making it a highly priced spice. The collected stigmas are the medicinally active component of the plant, but it takes about 36,000 flowers to yield just 1 pound of the stigmas, which also increases the value of this plant as a medicinal herb. Saffron has been used in traditional folk medicines and Ayurvedic health systems as a herbal sedative, digestive aid, anti-inflammatory, expectorant and adaptogenic agent for centuries. Saffron is known as a ‘yogavahi’ herb in Ayurveda as it acts as a catalyst for other herbs it is taken with.

What is affron®?

affron® is a premium Saffron ingredient standardized to 3.5% Lepticrosalides™, which is responsible for the beneficial properties and organoleptic properties of affron®. It is backed by six human clinical studies that have shown to improve quality sleep. affron® uses a patented low temperature proprietary extraction process that creates superior Saffron quality with long-lasting active stability.  This process results in the highest quality of Saffron while producing less industrial processing, energy and zero chemicals. affron® is internationally patented both with its formulation and effects on health with the lowest daily dose of only 28 mg. It is the world's first clinical studied version of Saffron proven to help sleep, mood, cognition and vitality. affron® is creating a buzz amongst academics and scientists as the first Saffron extract on the market to be supported with peer-reviewed clinical evidence to demonstrate positive benefits across sleep quality.

Issues with regular Saffron?

The Saffron market is full with products containing raw or dried Saffron, which will reduce the efficacy of Saffron, as they don’t hold the same active constituents as in a standardized Saffron extract such as affron®. There are also no other Saffron products on the market today that are backed by preclinical or clinical studies to prove its efficacy. 

Why do we use affron® in our Sleep Complex?

affron® is the most widely published Saffron extract in the world. Proven to help maintain a positive mood and get restorative sleep, every day. affron® contains Lepticrosalides® > 3.5% (crocins >3.5%, safranal 0.03%) by HPLC-DAD. Lepticrosalides® is a complex of bioactive compounds responsible for the beneficial and organoleptic properties of affron®. affron® genuine quality relies on local trusted sourcing, the selection of the Spanish species Crocus sativus L. and the exclusive and proprietary extraction process that uniquely concentrates and preserves the actives with low energy use.

Check Out The Scientific Studies Below


  1. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 16(6), 937–947.Lopresti, A. L., Smith, S. J., Metse, A. P., & Drummond, P. D. (2020).
  2. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64 Kell G, et al. 
  3. Epidemiology of Premenstrual Syndrome (PMS)-A Systematic Review and Meta-Analysis Study. Journal of clinical and diagnostic research : JCDR, 8(2), 106–109. A, D. M., K, S., A, D., & Sattar, K. (2014).
  4. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(8-9), 726–730. Fukui, H., Toyoshima, K., & Komaki, R. (2011).
  5. Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease. Journal of cardiovascular and thoracic research, 9(4), 200–208. Abedimanesh, N., Bathaie, S. Z., Abedimanesh, S., Motlagh, B., Separham, A., & Ostadrahimi, A. (2017).
  6. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo- controlled study. J Affect Disord. 2017 Jan 1;207:188-196. Lopresti AL, et al.
  7. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. J Affect Disord. 2018 May;232:349-357. Lopresti AL, et al.
  8. Sleep enhancement by saffron extract in randomised control trial, Japanese Pharmacology and Therapeutics. Japanese Pharmacology and Therapeutics. 2018 (8); 46:1407-1415. Nishide, A, et al.
  9. New clinical evidence of affron® efficacy as an adjunct treatment for unremitted depression. J Psychopharmacol. 2019. Nov;33(11):1415-1427. Lopresti AL, et al.
  10. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytotherapy research : PTR, 14(3), 149–152. Abe, K., & Saito, H. (2000).
  11. Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review. Critical reviews in food science and nutrition, 1–24. Advance online publication. Abu-Izneid, T., Rauf, A., Khalil, A. A., Olatunde, A., Khalid, A., Alhumaydhi, F. A., Aljohani, A., Sahab Uddin, M., Heydari, M., Khayrullin, M., Shariati, M. A., Aremu, A. O., Alafnan, A., & Rengasamy, K. (2020). 
  12. Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms. Avicenna journal of phytomedicine, 5(5), 365–375.Mokhtari-Zaer, A., Khazdair, M. R., & Boskabady, M. H. (2015). 
  13. Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review. Iranian journal of basic medical sciences, 19(5), 455–469. Khorasany, A. R., & Hosseinzadeh, H. (2016).
  14. Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review. Iranian journal of basic medical sciences, 22(4), 334–344. Zeinali, M., Zirak, M. R., Rezaee, S. A., Karimi, G., & Hosseinzadeh, H. (2019). 
  15. Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: A brief overview. Phytotherapy research : PTR, 32(12), 2364–2375. Leone, S., Recinella, L., Chiavaroli, A., Orlando, G., Ferrante, C., Leporini, L., Brunetti, L., & Menghini, L. (2018).

Here’s Why People Trust Us To Care For Their Body & Mind

  • We Create Unique Complexes

    We’ve explored all corners of the Earth to find nature’s most potent herbs, plants and fruits for human wellbeing. Individually, these ingredients have been used for centuries. Together, they can truly transform modern wellness. Our complexes use cutting edge science to synergise these ingredients in ways that maximise absorption, giving you the most powerful results. 

  • We’re Backed By Science

    Created by nature, proven by science. Each one of our Pillar ingredients is clinically peer-patented, using cutting edge methods and backed by extensive scientific literature. And because each one harnesses the highest bioavailability of each plant or herb, it’s hardly surprising that all three of our Pillar ingredients have won awards within the health and wellness space. 

  • We Honour Nature

    Our ethos is rooted in a deep respect for mother nature. After all, Earth has given us the gifts we need to nurture our bodies and mind for thousands of years; we simply need to reconnect to this truth. That’s why we use the purest plants, herbs and fruits in our complexes and include zero fillers, anti-caking agents, binders or preservatives. So you just get the good stuff, exactly as nature intended. 

  • We’re Sustainable & Ethically Sourced

    Our company honours what our planet has given us. That’s why we insist on full traceability and transparent suppliers when it comes to a green agenda and we’ve sourced the most eco-friendly options available for our packaging. What’s more, our partnership withOne Tree Planted means that you’re helping to reforest the planet, one order at a time