the world’s first clincally studied saffron

affron®

Using a patented low-temperature proprietary extraction process, ensuring top-notch Saffron quality with enduring active stability. It's the world’s first clinically studied Saffron, proven to aid sleep, cognition, and mood.

affron® is an

Award-Winning Herb

NutraIngredients 2022 - Ingredient of the Year: Healthy Ageing.

NutraIngredients 2022 - nominee in the Cognitive Function

USA Award-winner Ingredient for Cognitive Health 2020

"Clinical evidence of effectiveness in a range of health applications linked to ageing, including sleep, mood and menopause"

What is Saffron?

Saffron, obtained from the Crocus sativus flower, boasts a rich history over 3,500 years. Its cultivation is labor-intensive and time-consuming, contributing to its status as one of the most expensive spices. Traditionally, Saffron has been a staple in folk medicines and Ayurvedic practices, used as a herbal sedative, digestive aid, anti-inflammatory, and adaptogen for centuries. In Ayurveda, Saffron is particularly valued as a ‘yogavahi’ herb, known to enhance the effects of other herbs it is combined with.

What is affron®?

affron® sets a new standard in Saffron supplements, uniquely standardized to 3.5% Lepticrosalides™, the key to its beneficial and sensory properties. With the backing of six human clinical studies, affron® has proven its prowess in enhancing sleep quality. Its patented low-temperature extraction process ensures a high-quality Saffron with lasting active stability, achieved with minimal industrial processing, energy use, and no chemicals.

Affron®'s international patents cover both its unique formulation and its health benefits, with an effective daily dose of just 28 mg. Garnering attention from academics and scientists, affron® is the first Saffron extract backed by peer-reviewed clinical evidence, showcasing its positive impact on sleep quality.

The issue with regular Saffron?

The Saffron market is crowded with products featuring raw or dried Saffron, which often fall short in efficacy. This is because they lack the consistent active constituents found in a standardized extract like affron®. Furthermore, affron® stands alone as there are currently no other Saffron products on the market backed by preclinical or clinical studies to substantiate their effectiveness. This sets affron® apart as a uniquely reliable and proven choice in the world of Saffron supplements.

Scientific References

  1. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 16(6), 937–947.Lopresti, A. L., Smith, S. J., Metse, A. P., & Drummond, P. D. (2020).
  2. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64 Kell G, et al. 
  3. Epidemiology of Premenstrual Syndrome (PMS)-A Systematic Review and Meta-Analysis Study. Journal of clinical and diagnostic research : JCDR, 8(2), 106–109. A, D. M., K, S., A, D., & Sattar, K. (2014).
  4. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(8-9), 726–730. Fukui, H., Toyoshima, K., & Komaki, R. (2011).
  5. Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease. Journal of cardiovascular and thoracic research, 9(4), 200–208. Abedimanesh, N., Bathaie, S. Z., Abedimanesh, S., Motlagh, B., Separham, A., & Ostadrahimi, A. (2017).
  6. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo- controlled study. J Affect Disord. 2017 Jan 1;207:188-196. Lopresti AL, et al.
  7. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. J Affect Disord. 2018 May;232:349-357. Lopresti AL, et al.
  8. Sleep enhancement by saffron extract in randomised control trial, Japanese Pharmacology and Therapeutics. Japanese Pharmacology and Therapeutics. 2018 (8); 46:1407-1415. Nishide, A, et al.
  9. New clinical evidence of affron® efficacy as an adjunct treatment for unremitted depression. J Psychopharmacol. 2019. Nov;33(11):1415-1427. Lopresti AL, et al.
  10. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytotherapy research : PTR, 14(3), 149–152. Abe, K., & Saito, H. (2000).
  11. Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review. Critical reviews in food science and nutrition, 1–24. Advance online publication. Abu-Izneid, T., Rauf, A., Khalil, A. A., Olatunde, A., Khalid, A., Alhumaydhi, F. A., Aljohani, A., Sahab Uddin, M., Heydari, M., Khayrullin, M., Shariati, M. A., Aremu, A. O., Alafnan, A., & Rengasamy, K. (2020). 
  12. Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms. Avicenna journal of phytomedicine, 5(5), 365–375.Mokhtari-Zaer, A., Khazdair, M. R., & Boskabady, M. H. (2015). 
  13. Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review. Iranian journal of basic medical sciences, 19(5), 455–469. Khorasany, A. R., & Hosseinzadeh, H. (2016).
  14. Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review. Iranian journal of basic medical sciences, 22(4), 334–344. Zeinali, M., Zirak, M. R., Rezaee, S. A., Karimi, G., & Hosseinzadeh, H. (2019). 
  15. Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: A brief overview. Phytotherapy research : PTR, 32(12), 2364–2375. Leone, S., Recinella, L., Chiavaroli, A., Orlando, G., Ferrante, C., Leporini, L., Brunetti, L., & Menghini, L. (2018).

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Sleep

unwind. rest. recharge.

  • Helps to reduce sleep latency
  • Antioxidant support while sleeping

  • Wake up refreshed
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Locally Sourced & Manufactured in UK

Mass-Produced Overseas

Clinically Studied Ingredients

Poorly absorbed ingredients

Clean formula, no fillers

Uses fillers, and unnecessary additives

All in One Complex

Single-Ingredient Product

Locally Sourced & Manufactured in UK

Clinically Studied Ingredients

Clean formula, no fillers

All in One Complex

Mass-Produced Overseas

Poorly absorbed ingredients

Uses fillers, and unnecessary additives

Single-Ingredient Product

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